Acta Pediátrica Española

ISSN 2014-2986

Acta Pediátrica Española suspende su publicación
Tras 77 años ininterrumpidos de cita con sus lectores, la revista Acta Pediátrica Española va a suspender su publicación a partir de abril de 2020.
Mayo, empresa editora de la histórica cabecera, se ha visto obligada a tomar esta medida por razones estrictamente económicas derivadas de la caída de los ingresos publicitarios.
Los dos últimos números de Acta Pediátrica Española (los correspondientes a enero/febrero y marzo/abril) incluyen los artículos cuya publicación ha sido aceptada por el comité científico de la revista. Sin embargo, a partir de ahora ya no podemos atender nuevas peticiones de publicación de trabajos.
Desde Mayo queremos hacer público nuestro agradecimiento y reconocimiento a todos los excelentes profesionales que han participado en la dirección y en los comités científicos de la publicación, a los revisores, a los autores que nos han confiado sus trabajos, a nuestros lectores y a los anunciantes. Gracias a su apoyo hemos podido escribir juntos un pedacito de la historia de la pediatría española.

Ediciones Mayo S.A.

Información adicional

  • Num_publicacion 78(3-4)
  • Resumen_ingles

    Introduction: Extraintestinal manifestations in the celiac disease, in absence of the classic intestinal ones, are increasingly frequent. Gluten ataxia is a frequent manifestation in adults with celiac disease. It is, nonetheless, considered exceptional in pediatrics.

    Case report: We present a case of an 11-year-old boy with progressive ataxia difficult to diagnose, with practically normal serologic markers of celiac disease, diagnosed by intestinal biopsy and with a positive response to intravenous immunoglobulins and a gluten-free diet.

    Conclusion: It may be advisable in patients with cerebellar ataxia to perform an HLA typing along with an assessment of celiac disease serology, and in case of suspicion of performing oral digestive panendoscopy.

  • Palabras_clave_ingles Celiac disease cerebellar ataxia diagnosis gluten free diet
  • Todos_autores C. Sánchez Díaz, M. Marín Paton, D. Pascual Vaca, M.J. Balboa Vega, M.A. Sánchez Castilla
  • autores listados C. Sánchez Díaz, M. Marín Paton, D. Pascual Vaca, M.J. Balboa Vega, M.A. Sánchez Castilla
  • Titulo_ingles Celiac disease and cerebellar ataxia
  • Centros_trabajo Servicio de Pediatría. Hospital Universitario Virgen Macarena. Sevilla
  • Publicado en Acta Pediatr Esp. 2020; 78(3-4): e167-e170
  • copyright ©2020 Ediciones Mayo, S.A.
  • Tipo de Artículo Clínico (Microdatos) Case Reports
Publicado en Notas clínicas

Información adicional

  • Num_publicacion 75(7-8)
  • Resumen_ingles
    Introduction: A poor response of patients with celiac disease to the hepatitis B virus (HBV) vaccine has been reported, but there is controversy about its cause: it is unknown whether it is due to the presence of specific human leukocyte antigen genotypes among these patients, or by gluten intake. The aim of this study is to determine the immune response to the HBV vaccine in children with celiac disease in relation to gluten intake.
    Patients and methods: Quasi-experimental study. Vaccination status against HBV was compared in two groups of children with celiac disease: the first one was made up of children who received a conventional vaccination schedule at 0-2-6 months of age, and the second one was made up of those who did not respond to this primary vaccination and were revaccinated during the study, while they were following a gluten-free diet. Fisher’s exact test was used to determine the bilateral significance in the analysis of differences in response rates between the two groups.
    Results: Responsiveness to HBV vaccine was observed in 17 of the 43 (39.5%) children who received their primary vaccination in neonatal age. Twenty-four children were revaccinated as they were following a gluten-free diet and all (100%) responded properly, with a bilateral significance (p= 0.0000002) in Fisher’s exact test.
    Conclusions: Children with celiac disease have a lower response to HBV vaccine in neonatal age than when they are treated with a gluten-free diet. Our study suggests that the activity of the celiac disease, which is directly related to gluten intake, may be the main reason for this lack of response.
     
  • Palabras_clave_ingles Celiac disease Hepatitis B vaccines Vaccination Child Hepatitis B Gluten free diet
  • Todos_autores E. Navalón-Ramon, M. Coll-Esteve
  • autores listados E. Navalón-Ramon, M. Coll-Esteve
  • Correspondecia
    E. Navalón-Ramon. Sor Isabel de Villena, 29. 46819 Novetlè (Valencia).
    Correspondencia: emilinavalon@gmail.com
  • Titulo_ingles Immune response to hepatitis B vaccination in children with celiac disease
  • Centros_trabajo Centre de Salut Ontinyent-II. Ontinyent (Valencia)
  • Publicado en Acta Pediatr Esp. 2017; 75(7-8): e102-e108
  • copyright ©2017 Ediciones Mayo, S.A.
  • Fecha recepcion 5/05/16
  • Fecha aceptacion 25/08/16
  • Tipo de Artículo Clínico (Microdatos) Observational Study
Publicado en Originales

Información adicional

  • Num_publicacion 73(3)
  • Resumen_ingles

    Objective: To study the use of the new diagnostic criteria for celiac disease in the Castilla-La Mancha region, and the characteristics of these patients.
    Material and methods: Prospective data were collected in 7 hospitals within a descriptive transversal study that included patients diagnosed between July 2011 and the end of December 2012. The frequency with which they met requirements for diagnosis without intestinal biopsy based on the new criteria and the monitoring thereof were analyzed.
    Results: A total of 158 patients (63.3% female), with a median age of 5.5 years, were included in the study. In 54.4% of these patients celiac disease related symptoms were detected. The most frequent laboratory findings were ferropenia (29.7%), anemia (8.9%) and hypertransaminasemia (5.7%). At diagnosis, 79.1% of the patients had transglutaminase antibody titers 10 times above the upper limit of the normal range, with proven positive endomysial antibodies in 49.6% of them. Of the total patients, 39.2% fulfilled the new diagnostic criteria and 32.2% undergone an intestinal biopsy for different reasons. In all these cases, grade 3 lesions according to Marsh classification for celiac disease were found.
    Conclusions: The introduction of the new diagnostic criteria for celiac disease could lead to a 40% reduction in endoscopic procedures for these patients in our region. The interprovince variability in the access to certain techniques, does not allow the global use of these new criteria in the studied region where histology continues to be the main available option.

  • Palabras_clave_ingles Celiac disease Diagnostic criteria Castilla La Mancha
  • Todos_autores G. Galicia Poblet1*, E. Balmaseda Serrano2*, M.P. Sánchez Miranda3*, P. Donado Palencia3*, M.B. Martín-Sacristán4*, R. Solaguren Alberdi4*, J. Torrecilla Cañas5*, S. Cuadrado Martín6*, I. Navarro Vázquez7*, G. de las Casas Cámara8
  • autores listados G. Galicia Poblet, E. Balmaseda Serrano, M.P. Sánchez Miranda, P. Donado Palencia, M.B. Martín-Sacristán, R. Solaguren Alberdi, J. Torrecilla Cañas, S. Cuadrado Martín, I. Navarro Vázquez, G. de las Casas Cámara, Grupo de Trabajo «GastroMancha»
  • Correspondecia
    G. Galicia Poblet. Servicio de Pediatría. Hospital General Universitario de Guadalajara. Universidad de Alcalá de Henares. Donante de sangre, s/n. 19002 Guadalajara.
    Correo electrónico: gonzalogp78@gmail.com
  • Titulo_ingles Application of new criteria for diagnosis of celiac disease in Castilla-La Mancha
  • Centros_trabajo 1Servicio de Pediatría. Hospital General Universitario de Guadalajara. Universidad de Alcalá de Henares. 2Servicio de Pediatría. Complejo Hospitalario Universitario de Albacete. 3Servicio de Pediatría. Hospital General Universitario de Ciudad Real. 4Servicio de Pediatría. Hospital «Virgen de la Salud». Toledo. 5Servicio de Pediatría. Hospital «Virgen de la Luz». Cuenca. 6Servicio de Pediatría. Hospital General «Nuestra Señora del Prado». Talavera de la Reina (Toledo). 7Servicio de Pediatría. Hospital General de Almansa (Albacete). 8Servicio de Medicina Preventiva. Hospital Universitario «Infanta Elena». Valdemoro (Madrid). *Grupo de Trabajo «GastroMancha»
  • Publicado en Acta Pediatr Esp. 2015; 73(3): 60-64
  • copyright ©2015 Ediciones Mayo, S.A.
  • Fecha recepcion 12/07/14
  • Fecha aceptacion 8/10/14
  • Tipo de Artículo Clínico (Microdatos) Observational Study
Publicado en Originales

Información adicional

  • Num_publicacion 72(9)
  • Resumen_ingles

    Autoimmune hepatitis and celiac disease are two immune-mediated conditions, with proven association with each other. Idiopathic thrombocytopenic purpura (ITP) is an autoimmune or immune-based entity in which the existence of IgG antibodies against platelet surface causes thrombocytopenia. The association between autoimmune hepatitis with idiopathic thrombocytopenic purpura and between celiac disease and idiopathic thrombocytopenic purpura has been previously described. We report the case of a 4 year old girl who presents with anemia and Idiopathic thrombocytopenic purpura, along with celiac disease and autoimmune hepatitis.

  • Palabras_clave_ingles Autoimmune hepatitis Celiac disease Idiopathic thrombocytopenic purpura
  • Todos_autores J.C. Salazar Quero, A. Rodríguez Martínez, M. Rubio Murillo, B. Espín Jaime, A. Pizarro Martín
  • autores listados J.C. Salazar Quero, A. Rodríguez Martínez, M. Rubio Murillo, B. Espín Jaime, A. Pizarro Martín
  • Correspondecia
    J.C. Salazar Quero. Unidad de Digestivo Infantil. Unidad de Gestión Clínica de Pediatría. Hospitales Universitarios «Virgen del Rocío». Avda. Manuel Siurot, s/n. 41013 Sevilla.
    Correo electrónico: josesolrac@hotmail.com
  • Titulo_ingles Autoimmune hepatitis, celiac disease and idiopathic thrombocytopenic purpura in 4 year old girl
  • Centros_trabajo Unidad de Digestivo Infantil. Unidad de Gestión Clínica de Pediatría. Hospitales Universitarios «Virgen del Rocío». Sevilla
  • Publicado en Acta Pediatr Esp. 2014; 72(9): e315-e320
  • copyright ©2014 Ediciones Mayo, S.A.
  • Fecha recepcion 9/09/13
  • Fecha aceptacion 6/11/13
  • Tipo de Artículo Clínico (Microdatos) Case Reports
Publicado en Notas clínicas

Información adicional

  • Num_publicacion 72(9)
  • Resumen_ingles

    Introduction: The objective of the present research is to study the behavior of the faecal calprotectin in the pediatric coeliac disease, comparing its levels while receiving a diet with and without gluten. For the comparison, there were also included healthy children, and patients with diverse non-inflammatory digestive pathologies.
    Materials and methods: There have been collected stool samples from de novo coeliac patients (with gluten) and from follow-up coeliac patients (without gluten). As control groups, there were included healthy children without any digestive pathology and others with diverse digestive non-diagnosed disorders from the inflammatory bowel disease.
    Results: The faecal calprotectin was significantly higher in the coeliac patients with gluten (119.2 ± 122.6 µg/g) than in the patients with the gluten-free diet (21.5 ± 24.7 µg/g). The later showed similar values to those in the healthy control group.
    Conclusions: The faecal calprotectin is higher in the coeliac patients with gluten ingestion than in the coeliac patients with the gluten-free diet and in the healthy group. This could be used as a marker for early detection of gluten ingestion.

  • Palabras_clave_ingles Faecal calprotectin Coeliac disease Children
  • Todos_autores F. Clemente Yago1, F. Clemente Bellido2, O. Manrique Moral1, E. Pérez Lledó1
  • autores listados F. Clemente Yago, F. Clemente Bellido, O. Manrique Moral, E. Pérez Lledó
  • Correspondecia
    F. Clemente Yago. Unidad de Medicina Digestiva Infantil. Servicio de Pediatría. Hospital General Universitario de Alicante. Pintor Baeza, 12. 03010 Alicante.
    Correo electrónico: clemente_fer@gva.es
  • Titulo_ingles Usefulness of the faecal calprotectin on the pediatric coeliac disease
  • Centros_trabajo 1Unidad de Medicina Digestiva Infantil. Servicio de Pediatría. Hospital General Universitario de Alicante. 2Alumno de 6.º grado de Medicina. Universidad Católica San Vicente Ferrer. Valencia
  • Publicado en Acta Pediatr Esp. 2014; 72(9): 182-186
  • copyright ©2014 Ediciones Mayo, S.A.
  • Fecha recepcion 18/03/14
  • Fecha aceptacion 31/03/14
  • Tipo de Artículo Clínico (Microdatos) Observational Study
Publicado en Originales

Información adicional

  • Num_publicacion 71(7)
  • Resumen_ingles

    Celiac disease (CD) is an enteropathy consequence of an aberrant immune response mediated by T lymphocytes against gluten. For the development of the disease it is necessary a genetic predisposition and gluten exposure; however, other environmental factors (dietary, infections, increased intestinal permeability...) act as triggers. The main genetics factors associated with celiac disease are major histocompatibility complex class II genes, that encode human leukocyte antigen HLA-DQ2 and HLA-DQ8. Recent genome-wide association studies have led to the identification of several non-HLA risk loci for celiac disease. We present an update on these genes and genetics differences between healthy subjects, celiac disease and potential celiac.

  • Palabras_clave_ingles Celiac disease HLA Genetics
  • Todos_autores B. Fernández Caamaño, A. Alcolea Sánchez, L.N. Magallares García, V. Díaz Marugán, I. Polanco Allué
  • autores listados B. Fernández Caamaño, A. Alcolea Sánchez, L.N. Magallares García, V. Díaz Marugán, I. Polanco Allué
  • Correspondecia
    I. Polanco Allué. Servicio de Gastroenterología y Nutrición Infantil. Hospital Infantil Universitario «La Paz». Paseo de la Castellana, 261. 28046 Madrid.
    Correo electrónico: ipolanco.hulp@salud.madrid.org
  • Titulo_ingles Genetic susceptibility in celiac disease. Uptodate
  • Centros_trabajo Servicio de Gastroenterología y Nutrición Infantil. Hospital Infantil Universitario «La Paz». Madrid
  • Publicado en Acta Pediatr Esp. 2013; 71(7): e165-e169
  • copyright ©2013 Ediciones Mayo, S.A.
  • Fecha recepcion 14/01/2013
  • Fecha aceptacion 31/01/2013
Publicado en Revisión

Información adicional

  • Num_publicacion 64(3)
  • Resumen_ingles

    Celiac disease is an autoimmune disease that has important consequences during childhood. Although the factors that trigger its development in genetically predisposed patients are unknown, it is thought that fetal factors, among others, could play a role in the later development of the disease. We report the case of a girl who presented intrauterine growth retardation and was later diagnosed as having celiac disease. Her mother had had a viral infection during pregnancy and we speculate that this circumstance could have caused both the intrauterine growth retardation and the development of celiac disease. The similarity between viral antigens and gliadin could explain why intrauterine exposure to those antigens would produce sensitization to gliadin and, thus, a later exposure to gluten, when introduced into the diet, would trigger the mechanisms of the disease.

  • Palabras_clave_ingles Celiac disease intrauterine growth retardation intrauterine viral infection
  • Todos_autores S.T. Jiménez Gil de Muro1, M. Moros Peña, M.D. Mínguez Herrero, L. Ros Mar1
  • autores listados S.T. Jiménez Gil de Muro, M. Moros Peña, M.D. Mínguez Herrero, L. Ros Mar
  • Correspondecia
    S.T. Jiménez Gil de Muro. Fundación Hospital Calahorra. Ctra. de Logroño, s/n. 26500 Calahorra (La Rioja).
    Correo electrónico: silviajgdm@yahoo.es
  • Titulo_ingles Intrauterine growth retardation and celiac disease: a coincidence or a causal relationship?
  • Centros_trabajo Centro de Salud Casablanca. 1Unidad de Gastroenterología y Nutrición Pediátrica. Hospital Infantil Universitario «Miguel Servet». Zaragoza
  • Publicado en Acta Pediatr Esp. 2006; 64: 123-124
  • copyright ©2006 Ediciones Mayo, S.A.
  • Fecha recepcion 17/01/2004
  • Fecha aceptacion 09/03/2005
Publicado en Notas clínicas

Información adicional

  • Num_publicacion 65(10)
  • Resumen_ingles

    The authors report the case of a 2-year-old infant with no weight gain over a four-month period, in the absence of gastrointestinal symptoms. An analysis revealed elevated serum transaminase levels (AST: 173, ALT: 425), with no other clinical or analytical evidence of chronic or infectious liver disease.

    Twenty days later, as the elevated transaminase levels persisted, serum IgA anti-tissue transglutaminase and anti-gliadin antibodies were determined, and were found to be elevated. An intestinal biopsy revealed subtotal villous atrophy, lymphocytosis and crypt hyperplasia. After two months of a gluten-free diet, the transaminase levels were normal.

  • Palabras_clave_ingles Celiac disease elevated serum transaminases
  • Todos_autores R.M. Vázquez Gomis, N. Izquierdo Fos, J.A. Carmona Valera, C. Vázquez Gomis, F.J. Chicano Marín
  • autores listados R.M. Vázquez Gomis, N. Izquierdo Fos, J.A. Carmona Valera, C. Vázquez Gomis, F.J. Chicano Marín
  • Correspondecia
    R.M. Vázquez Gomis. Servicio de Pediatría. Hospital «Virgen de la Vega». Román Alberca, s/n. 30008 Murcia.
    Correo electrónico: nachoyros@yahoo.es
  • Titulo_ingles Persistent elevation of serum transaminase levels in the absence of gastrointestinal symptoms: should celiac disease be considered?
  • Centros_trabajo Servicio de Pediatría. Hospital «Virgen de la Vega». Murcia
  • Publicado en Acta Pediatr Esp. 2007; 65(10): 527-528
  • copyright ©2007 Ediciones Mayo, S.A.
  • Fecha recepcion 16/05/07
  • Fecha aceptacion 26/05/07
Publicado en Notas clínicas

Información adicional

  • Num_publicacion 66(1)
  • Resumen_ingles

    We report the case of a 7 and a half-year-old girl who was diagnosed as having celiac disease on the basis of compatible clinical features, serological tests and jejunal biopsy. The course was favourable after a gluten-free diet. One year later, she presented bloody stools, with laboratory tests and colonoscopic findings that suggested ulcerative pancolitis. As the association between celiac disease and inflammatory bowel disease has rarely been reported in children, we consider it to be of great interest to present our case and review the available literature.

  • Palabras_clave_ingles Celiac disease inflammatory bowel disease malabsorption syndromes
  • Todos_autores M. Carballal Mariño, E. Cavanilles Walker, A. Solar Boga, L. García Alonso
  • autores listados M. Carballal Mariño, E. Cavanilles Walker, A. Solar Boga, L. García Alonso
  • Correspondecia
    M. Carballal Mariño. Manuel Azaña, 19, 1.º B. 15011 A Coruña.
    Correo electrónico: marta.carballal.marino@sergas.es
  • Titulo_ingles Association between celiac disease and ulcerative pancolitis: a case report and review of the literature
  • Centros_trabajo Servicio de Gastroenterología Pediátrica. Hospital Materno Infantil «Teresa Herrera»-Hospital «Juan Canalejo». A Coruña
  • Publicado en Acta Pediatr Esp. 2008; 66(1): 32-34
  • copyright ©2008 Ediciones Mayo, S.A.
  • Fecha recepcion 29/10/07
  • Fecha aceptacion 30/10/07
Publicado en Notas clínicas

Información adicional

  • Num_publicacion 65(3)
  • Resumen_ingles

    In most cases, bowel intussusception in children is idiopathic. Secondary causes, such as celiac disease, are rare. Intussusception associated with celiac disease usually presents in an atypical way and resolves spontaneously. The knowledge of the possible association of these two conditions is important because it can lead to an early diagnosis of celiac disease, which should be suspected particularly in cases of recurrent intussusception. A gluten-free diet prevents the recurrence of intussusception.

  • Palabras_clave_ingles Bowel intussusception celiac disease
  • Todos_autores J. Guerrero Vázquez, J.L. Luengo Casasola, J. Guerrero Fernández1, P. de Paz Aparicio, M. Vicente Cuevas, C. Collantes García
  • autores listados J. Guerrero Vázquez, J.L. Luengo Casasola, J. Guerrero Fernández, P. de Paz Aparicio, M. Vicente Cuevas, C. Collantes García
  • Correspondecia
    J. Guerrero Vázquez. Avda. Virgen del Carmen, 23, 3.º C. 11201 Algeciras (Cádiz).
    Correo electrónico: jguerrerovqz@yahoo.es
  • Titulo_ingles Recurrent bowel intussusception and celiac disease
  • Centros_trabajo Hospital «Punta de Europa». Algeciras (Cádiz). 1Clínica Infantil «La Paz». Madrid
  • Publicado en Acta Pediatr Esp. 2007; 65(3): 134-136
  • copyright ©2007 Ediciones Mayo, S.A.
  • Fecha recepcion 09/11/06
  • Fecha aceptacion 17/11/06
Publicado en Notas clínicas
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